gastadv {surrosurv}

Individual data from the advanced GASTRIC meta-analysis

Description

The gastadv dataset contains individual data (overall and progression-free survival) of 4069 patients with advanced/recurrent gastric cancer from 20 randomized trials of chemotherapy.

Usage

data(gastadv)

Format

A dataframe with variables:

timeT:

Overall survival time (days).

statusT:

Overall survival indicator (0=censored, 1=death).

timeS:

Progression-free survival time (days).

statusS:

Progression-free survival indicator (0=censored, 1=progression on death).

trialref:

Trial indicator

trt:

Treatment arm (-0.5 = control, 0.5=chemotherapy).

id:

Patient identifier.

Source

The authors thank the GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group for permission to use their data. The investigators who contributed to GASTRIC are listed in Paoletti et al (2013) and GASTRIC (2013). The GASTRIC Group data are available within the surrosurv package for research purposes, under the conditions that (1) the research be scientifically appropriate, (2) the confidentiality of individual patient data be protected, (3) the results of the analyses be shared with the GASTRIC Group prior to public communication, (4) the source of data be fully acknowledged as above, and (5) resulting data and results be further shared with the research community.

References

Paoletti X, Oba K, Bang Y-J, et al. Progression-free survival as a surrogate for overall survival in advanced/recurrent gastric cancer trials: a meta-analysis. J Ntl Cancer Inst, 105(21):1667-70, 2013. doi: 10.1093/jnci/djt269.

The GASTRIC group. Role of chemotherapy for advanced/recurrent gastric cancer: An individual-patient-data meta-analysis. Eur J Cancer, 49(7):1565-77, 2013. doi: 10.1016/j.ejca.2012.12.016.

Buyse M, Molenberghs G, Paoletti Xavier et al. Statistical evaluation of surrogate endpoints with examples from cancer clinical trials. Biom J, 58(1):104-32, 2016. doi: 10.1002/bimj.201400049

Examples

  ## Not run: 
    data('gastadv')
    allSurroRes <- surrosurv(gastadv, c('Clayton', 'PoissonTIa'), verbose = TRUE)
    convergence(allSurroRes)
    allSurroRes
    predict(allSurroRes)
    plot(allSurroRes)
  
## End(Not run)