mHP.b {sp23design}

Compute the modified Haybittle-Peto boundary

Description

Compute the modified Haybittle-Peto boundary

Usage

mHP.b(mu = c(0, 0), v = c(1, 2), alpha = 0.05, eps = 1/2, side = c("one", "two"))

Arguments

mu

The mean vector

v

The variance vector, usually proportional to information in calendar time

alpha

The significance desired

eps

The fraction of alpha to use

side

one-sided or two-sided (one or two)

Details

Compute the modified Haybittle-Peto boundary

Value

the modified Haybittle-Peto boundary

Author(s)

Mei-Chiung Shih, Balasubramanian Narasimhan, Pei He

References

Lai, Tze Leung and Lavori, Philip W. and Shih, Mei-Chiung. Sequential Design of Phase II-III Cancer Trials, Statistics in Medicine, Volume 31, issue 18, p.1944-1960, 2012.