Simulate and Model Family Pedigrees with Structured Founders


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Documentation for package ‘simfam’ version 1.1.6

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admix_fam Calculate admixture matrix of a pedigree with known admixture of founders
admix_last_gen Calculate admixture matrix for last generation of a pedigree with admixture of founders
draw_sex Draw sex values randomly for a list of individuals
fam_ancestors Construct an ancestors-only pedigree for one person 'G'-generations deep
geno_fam Draw random genotypes on a pedigree with known founder genotypes
geno_last_gen Draw random genotypes for last generation of a pedigree with known founder genotypes
kinship_fam Calculate kinship matrix of a pedigree with structured founders
kinship_last_gen Calculate kinship matrix for last generation of a pedigree with structured founders
prune_fam Remove non-ancestors of a set of individuals from pedigree
recomb_admix_inds Reduce haplotype ancestry data to population ancestry dosage matrices
recomb_fam Draw recombination breaks for autosomes from a pedigree
recomb_geno_inds Reduce haplotype data to genotype matrix
recomb_haplo_inds Construct haplotypes of individuals given their ancestral blocks and the ancestral haplotype variants
recomb_init_founders Initialize chromosome structures for founders
recomb_last_gen Draw recombination breaks for autosomes for last generation of a pedigree
recomb_map_fix_ends_chr Extrapolate and shift recombination map of one chromosome to ends
recomb_map_hg Simplified recombination maps for human genomes
recomb_map_hg37 Simplified recombination maps for human genomes
recomb_map_hg38 Simplified recombination maps for human genomes
recomb_map_inds Map recombination breaks from genetic positions to base pair coordinates
recomb_map_simplify_chr Simplify recombination map of one chromosome to a desired numerical precision
sim_pedigree Construct a random pedigree