TS_signature {signatureSurvival}

A signature constructed with a set of tumor suppressor genes

Description

TS_signature was constructed with a set of 26 tumor suppressor genes screened from microarray data GSE19804 and cohorts GSE18842, GSE40419, and GSE21933 using differential analysis and bioinformatics methods.

Usage

data("TS_signature")

Format

A data frame with 28 observations on the following 2 variables.

probeid

a character vector

gene

a character vector

Details

TS signature has 26 tumor suppressor genes (26 probeids). These genes are normally expressed but repressed in cancer or tumor cells. Therefore, a TS signature also has low expression in normal tissues but high expression in cancer cells of patients.

References

Zhang, C., Jiang, M., Zhou, N. et al. Use tumor suppressor genes as biomarkers for diagnosis of non-small cell lung cancer. Sci Rep 11, 3596 (2021). https://doi.org/10.1038/s41598-020-80735-x.

Examples

data(ST_signature)