handle_hyper_mutation {sigminer}

Handle Hypermutant Samples

Description

This can be used for SNV/INDEL count matrix. For copy number analysis, please skip it.

Usage

handle_hyper_mutation(nmf_matrix)

Arguments

nmf_matrix

a matrix used for NMF decomposition with rows indicate samples and columns indicate components.

Value

a matrix.

References

Kim, Jaegil, et al. "Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors." Nature genetics 48.6 (2016): 600.