HH_S1F {shazam}

Human heavy chain, silent, 1-mer, functional substitution model.

Description

1-mer substitution model of somatic hypermutation based on analysis of silent mutations in functional heavy chain Ig sequences from Homo sapiens.

Usage

HH_S1F

Format

A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.

Note

HH_S1F replaces HS1FDistance in versions of SHazaM prior to 0.1.5.

References

1. Yaari G, et al. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013 4(November):358.

See Also

See HKL_S1F for the human light chain 1-mer substitution model and MK_RS1NF for the mouse light chain 1-mer substitution model.