DLBCL {secure}

Chemotherapy data

Description

A list of two components.

Usage

data(DLBCL)

Format

A list with two components:

Y

Chromatin immunoprecipitation. A matrix of 180 rows and 661 columns.

classIndex

Group index of 180 patients where 1,2,3 corresponds to OxPhos, BCR and HR groups respectively.

Details

Matrix Y : Gene expression dataset from the patients with diffuse large-B-cell lymphoma (DLBCL) after chemotherapy. The data has been used for unsupervised analysis i.e. Biclustering. The data consists of expression levels of q = 661 genes from n =180 patients. Among the patients, 42, 51 and 87 of them were classified to OxPhos, BCR and HR groups, respectively. The data thus form an n by q matrix Y whose rows represent the subjects and columns correspond to the genes, and used in Rosenwald (2002).

classIndex: Out of OxPhos (oxidative phosphorylation), BCR(Bcell response) and HR (host response), the index corresponds to the groups in which these 180 subjects belongs as classified by Hoshida (2007).

References

Rosenwald, A., Wright, G., Chan, W. C., Connors, J. M., Campo, E., Fisher, R. I., Gascoyne, R. D., Muller-Hermelink, H. K., Smeland, E. B., Giltnane, J. M. et al. (2002) The use of molecular profling to predict survival after chemotherapy for diffuse large-b-cell lymphoma. New England Journal of Medicine, 346, 1937-1947.

Hoshida, Y., Brunet, J.-P., Tamayo, P., Golub, T. R. and Mesirov, J. P. (2007) Subclass mapping: Identifying common subtypes in independent disease data sets. PLoS ONE, 2, e1195.

Examples

# data(DLBCL)