PocockBound {sasLM}

Pocock (fixed) Bound for the cumulative Z-test with a final target alpha-value

Description

Cumulative alpha values with cumulative hypothesis test with a fixed upper bound z-value in group sequential design.

Usage

  PocockBound(K=2, alpha=0.05, side=2)

Arguments

K

total number of tests

alpha

alpha value at the final test

side

1=one-side test, 2=two-side test

Details

Pocock suggested a fixed upper bound z-value for the cumulative hypothesis test in group sequential designs.

Value

a fixed upper bound z-value for the K times repated hypothesis test with a final alpha-value. Attributes are;

ti

time of test, Even-interval is assumed.

cum.alpha

cumulative alpha valued

Author(s)

Kyun-Seop Bae [e-mail]

References

Reboussin DM, DeMets DL, Kim K, Lan KKG. Computations for group sequential boundaries using the Lan-DeMets function method. Controlled Clinical Trials. 2000;21:190-207.

Examples

  PocockBound(K=2) # Z-value of upper bound for the two-stage design