fluEnrich {rvalues}

Flu Enrichment Data

Description

Gene-set enrichment for genes that have been identified as having an effect on influenza-virus replication.

Usage

data(fluEnrich)

Format

A data frame with 5719 observations on the following 3 variables.

nflugenes

number of genes both annotated to the given GO term and in the collection of flu genes

setsize

number of genes annotated to the given GO term

GO_terms

the GO (gene ontology) term label

Details

These data were produced by associating the 984 genes (the collection of flu genes) identified in the Hao et al. (2013) meta-analysis with gene ontology (GO) gene sets (GO terms). In total, 17959 human genes were annotated to at least one GO term and 16572 GO terms were available, though this data set only contains the 5719 terms which annotated between 10 and 1000 human genes.

References

Hao, L. Q. He, Z. Wang, M. Craven, M. A. Newton, and P. Ahlquist (2013). Limited agreement of independent RNAi screens for virus-required host genes owes more to false-negatives than false-positive factors. PLoS computational biology, 9, 9, e1003235.