data {roben} | R Documentation |
simulated data for demonstrating the features of roben
Description
Simulated gene expression data for demonstrating the features of roben.
Usage
data("GxE_small")
data("GxE_large")
Format
GxE_small consists of five components: X, Y, E, clin and coeff. coeff contains the true values of parameters used for generating Y.
GxE_large contains larger datasets: X2, Y2, E2 and clin2
Details
The data model for generating Y
Use subscript to denote the
th subject. Let
, (
) be
independent and identically distributed random vectors.
is a continuous response variable representing the
disease phenotype.
is the
–dimensional vector of G factors. The environmental factors and clinical covariates
are denoted as the
-dimensional vector
and the
-dimensional vector
, respectively.
The
follows some heavy-tailed distribution.
Considering the following model:
where is the intercept;
's,
's,
's and
's are
the regression coefficients for the clinical covariates, environmental factors, genetic factors and G
E interactions, respectively.
Define and
, where
.
The model can be written as
where the coefficient vector represents all the main and interaction effects corresponding to the
th genetic measurement.
The object coeff in GxE_small is a list of four components, corresponding to ,
's,
's and
's.
See Also
Examples
data(GxE_small)
dim(X)
print(coeff)
data(GxE_large)
dim(X)
print(coeff)