ethylene {rmp}

Developmental toxicity study of ethylene glycol in mice

Description

Data from the developmental toxicity study of ethylene glycol in mice conducted by the National Toxicology Program. Pregnant mice were assigned to dose groups of 0, 750, 1,500 or 3,000 mg/kg per day, with the number of implants measured for each mouse at the end of the experiment. Group sizes are 25, 24, 23 and 23, respectively.

Usage

data(ethylene)

Format

A data frame with 1192 observations on the following 7 variables.

id

identifyer for pregnant mouse

dose

dose of ethylene glycol

weight

weight of the fetus

sex

sex of the fetus

impl

number of implants in the pregnant mouce

litsz

size of the relative litter

malf

presence of malformation in the fetus

References

Price, C. J., Kimmel, C. A., Tyl, R. W., and Marr, M. C. (1985) "The developemental toxicity of ethylene glycol in rats and mice" Toxicological and Applied Pharmacology 81, 113-127.

Examples

data(ethylene)
implants <- tapply(ethylene$impl, FUN=mean, INDEX=ethylene$id)

summary(implants)
m <- mean(implants)
v <- var(implants)
hist(implants, main=paste("Histogram of the number of implants (Mean = ",
round(m,2), ", Var = ", round(v,2),")"))