profileCombinations {retriever} | R Documentation |
Compute drug combination response signatures
Description
Returns the average of every possible two response profile non-redundant combination from the input matrix
Usage
profileCombinations(responseProfiles)
Arguments
responseProfiles |
A matrix of response profiles for drugs (rows are genes, columns are drugs) |
Value
A matrix with genes in the rows and profiles combination in the columns. The values represent the expected transcriptional response of the cells (used as input of retriever) to a drug combination.
Examples
# Loading robust profiles across different breast cancer cell lines generated by retriever.
# BRCA <- retriever(cellLines = c('MDAMB231', 'MCF7', 'SKBR3', 'HS578T', 'BT20'))
BRCA <- read.csv(system.file("BRCA.csv",package="retriever"), row.names = 1)
dim(BRCA)
# [1] 1001 125
# Computing response profiles combinations
combinationsBRCA <- profileCombinations(BRCA)
dim(combinationsBRCA)
# [1] 1001 7750
[Package retriever version 0.2.1 Index]