TTRR.RRTT {replicateBE} | R Documentation |
Reference Datasets for TTRR|RRTT Designs
Description
Dataset obtained by simulations to be evaluated by method.A()
and/or method.B()
.
Format
Reference Dataset 28
64 subjects. Balanced (64 subjects in both sequences) and complete. No outliers.
A data frame with 256 observations on the following 5 variables:- rds28
-
subject
a factor with 64 levels: 1, 2, ..., 64 period
a factor with 4 levels: 1, 2, 3, 4 sequence
a factor with 2 levels: TTRR, RRTT treatment
a factor with 2 levels: T, R PK
a numeric vector of pharmacokinetic responses acceptable for reference-scaling (generally Cmax)
Details
Dataset | N | CVwR (%) | Evaluation |
rds28 | 64 | <30 | method.A() , method.B()
|
Note
In software sequences and treatments are ranked in lexical order. Hence, executing str()
or summary()
will show sequence
as "RRTT", "TTRR"
and treatment
as "R", "T"
. In BE – by convention – sequences are ordered with T
first. The package follows this convention.
Author(s)
Helmut Schütz (R-code for simulations by Detlew Labes)
Source
Dataset | Origin | Description |
rds28 | R | Simulated with CVwT = CVwR = 35%, CVbT = CVbR = 75%, GMR 0.90. |
Examples
str(rds28)
summary(rds28[1:5])
[Package replicateBE version 1.1.3 Index]