| permissible_uncertainty {reflimR} | R Documentation |
Tolerance intervals of estimated and target limits
Description
Returns the permissible uncertainty of reference limits.
Usage
permissible_uncertainty(lower.limit, upper.limit, apply.rounding = TRUE)
Arguments
lower.limit |
positive number indicating the lower limit of the reference interval |
upper.limit |
positive number indicating the upper limit of the reference interval |
apply.rounding |
Boolean indicating whether the tolerance limits should be rounded |
Details
The tolerance limits (also called equivalence limits) indicate the permissible uncertainty of a reference limit from a medical point of view (in contrast to the confidence interval, which reflects the statistical point of view). The calculation is based on a recommendation made by the DGKL [1, 2].
Value
Tolerance intervals for the lower and upper reference limits (ranging from lower.lim.low to lower.lim.upp for the lower reference limit and from upper.lim.low to upper.lim.upp for the upper reference limit)
References
1. Haeckel R et al. Permissible limits for uncertainty of measurement in laboratory medicine. Clin Chem Lab Med 2015;53:1161–71. doi:10.1515/cclm-2014-0874.
2. Haeckel R et al. Equivalence limits of reference intervals for partitioning of population data. J Lab Med 2016; 40: 199-205. doi:10.1515/labmed-2016-0002.
Examples
permissible_uncertainty(lower.limit = 10, upper.limit = 50)
permissible_uncertainty(10, 50, FALSE)