radpc {random.cdisc.data}

Pharmacokinetics Analysis Dataset (ADPC)

Description

Function for generating a random Pharmacokinetics Analysis Dataset for a given Subject-Level Analysis Dataset.

Usage

radpc(
  adsl,
  avalu = "ug/mL",
  constants = c(D = 100, ka = 0.8, ke = 1),
  duration = 2,
  seed = NULL,
  na_percentage = 0,
  na_vars = list(AVAL = c(NA, 0.1)),
  cached = FALSE
)

Arguments

adsl

(data.frame)
Subject-Level Analysis Dataset (ADSL).

avalu

(character)
Analysis value units.

constants

(⁠character vector⁠)
Constant parameters to be used in formulas for creating analysis values.

duration

(numeric)
Duration in number of days.

seed

(numeric)
Seed to use for reproducible random number generation.

na_percentage

(proportion)
Default percentage of values to be replaced by NA.

na_vars

(list)
A named list where the name of each element is a column name of ds. Each element of this list should be a numeric vector with two elements:

• seed (numeric)
  The seed to be used for this element - can be NA.

• percentage (proportion)
  Percentage of elements to be replaced with NA. If NA, na_percentage is used as a default.

cached

boolean whether the cached ADPC data cadpc should be returned or new data should be generated. If set to TRUE then the other arguments to radpc will be ignored.

Details

One record per study, subject, parameter, and time point.

Value

data.frame

Examples

adsl <- radsl(N = 10, seed = 1, study_duration = 2)

adpc <- radpc(adsl, seed = 2)
adpc

adpc <- radpc(adsl, seed = 2, duration = 3)
adpc