| nf1 {qtlbook} | R Documentation |
Neurofibromatosis type 1 backcross data
Description
Data from a backcross experiment on neurofibromatosis type I. All individuals carry the NPcis mutation, received either from their mother or from their father.
Usage
nf1
Format
An object of class cross. See qtl::read.cross()
for details.
Details
Backcrosses (C57BL/6J x A/J) x C57BL/6J and C57BL/6J x (A/J x C57BL/6J) with
a total of 254 individuals. Individuals received the NPcis mutation
from either their mother or their father (indicated by the phenotype
from.mom. The major phenotype, affected indicates whether the
mice were affected (1) or unaffected (0) with neurofibromatosis type 1.
References
Reilly, K. M., Broman, K. W., Bronson, R. T., Tsang, S., Loisel, D. A., Christy, E. S., Sun, Z., Diehl, J., Munroe, D. J. and Tuskan, R. G. (2006) An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Research 66, 62–68. #' @source Karlyne Reilly, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, kreilly@ncifcrf.gov
See Also
link{gutlength} link{iron}, link{myocard},
link{ovar}, link{trout}
Examples
data(nf1)
library(qtl)
plot(nf1)