gutlength {qtlbook}

Gut length intercross data

Description

Data from a mouse intercross experiment on gut length, including both sexes. All individuals carry the Sox10^{Dom} mutation.

Usage

gutlength

Format

An object of class cross. See qtl::read.cross() for details.

Details

A mouse intercross between C3HeBFeJ (C3) and C57BL/6J (B6), with one F1 parent carrying the Sox10^{Dom} mutation. There are 1068 mice from reciprocal intercrosses. Over 2000 mice were generated, but only those individuals heterozygous at Sox10^{Dom} were genotyped and included in the data set. Sox10 is on chromosome 15, and so that chromosome exhibits an unusual segregation pattern. Some mice received the mutation from their mother and some from their father.

The primary phenotype here is gut length (in cm). The phenotype cross indicates the cross used to generate an animal.

Source

E. Michelle Southard-Smith, Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, [e-mail]

References

Owens, S. E., Broman, K. W., Wiltshire, T., Elmore, J. B., Bradley, K. M., Smith, J. R. and Southard-Smith, E. M. (2005) Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10^{Dom} model of Hirschsprung disease. Hum. Mol. Genet. 14, 1549–1558.

Broman, K. W., Sen, 'S, Owens, S. E., Manichaikul, A., Southard-Smith, E. M. and Churchill G. A. (2006) The X chromosome in quantitative trait locus mapping. Genetics 174, 2151–2158.

See Also

iron, myocard, nf1, ovar, trout

Examples

data(gutlength)
library(qtl)
plot(gutlength)