calc.par {qpNCA}

Calculate NCA Parameters

Description

Calculates PK parameters for which half-life is not needed in the calculation for each PK curve defined using by.

Usage

calc.par(
  x,
  by = character(0),
  tau = NA,
  tstart = NA,
  tend = NA,
  teval = NA,
  route = "EV",
  method = 1
)

Arguments

x

contains all data after time/concentration deviation corrections obtained from correct.time and correct.conc

by

column names in x indicating grouping variables

tau

dosing interval (for multiple dosing); NA (default) for if single dose; x$tau overrides

tstart

start time of partial AUC (start>0); NA (default) if not requested; x$tstart overrides

tend

end time of partial AUC; NA (default) if not requested; x$tend overrides

teval

user selected AUC interval; NA (default) if not requested; x$teval overrides

route

route of drug administration ("EV","IVB","IVI"); x$route overrides

method

method for trapezoidal rule

• 1: linear up - linear down

• 2: linear up - logarithmic down

• 3: linear before first Tmax, logarithmic after first Tmax

Value

A dataset with estimates for the following parameters, one observation per subject:

Parameter	Description
t0.ok	flags if t=0 concentration could be corrected/imputes. If not, no AUCs starting at t=0 are calculated
tlast.ok	flags if there is at least one measurable concentration. If not, no AUClast can be calculated
tlast	time of last sample with measurable concentration
clast.obs	observed concentration at tlast
aucall	auc calculated over all observations, including values below LOQ (which are set to 0)
auclast	auc calculated using all observations up to and including the last measurable concentration (clast.obs at tlast)
aumcall	aumc calculated over all observations, including values below LOQ (which are set to 0)
aumclast	aumc calculated using all observations up to and including the last measurable concentration (clast.obs at tlast)
tau	the dosing interval (if specified)
calc.tau	flags if AUCtau could be calculated
auctau	auc calculated over the dosing interval, only calculated if tau is specified
aumctau	aumc calculated over the dosing interval, only calculated if tau is specified
teval	user selected AUC interval starting at t=0 (if specified)
calc.teval	flags if AUCteval could be calculated
aucxx	auc calculated from t=0 up to/including teval, only calculated if teval is specified (xx is substituted by teval)
calc.part	flags if AUCpart could be calculated
tstart	start time of partial AUC (if specified)
tend	end time of partial AUC (if specified)
aucx_y	partial auc from time=x up to/including time=y, where x>0, only calculated if tstart and tend are specified
c0	back-extrapolated concentration at t=0 for IV bolus administration
area.back.extr	area back-extrapolated to 0

Examples

example(correct.conc)
par <- x %>% calc.par(by = 'subject')
par %>% head