create_data_simulation {psborrow2}

Data Simulation

Description

Data Simulation

Usage

create_data_simulation(
  baseline,
  coefficients = numeric(),
  treatment_hr = 1,
  drift_hr = 1,
  event_dist,
  fixed_external_data
)

Arguments

baseline

BaselineObject from create_baseline_object()

coefficients

Named vector of coefficients for linear predictor. Must correspond to variables in baseline object

treatment_hr

Default treatment hazard ratio for simulations. Alternative simulation settings can be specified in generate.

drift_hr

Default drift hazard ratio between internal and external arms. Alternative simulation settings can be specified in generate.

event_dist

Specify time to event distribution with SimDataEvent object from create_event_dist()

fixed_external_data

A data.frame containing external control data. It must contain columns eventtime, status and all of the variables named in coefficients. If present, trt must be 0 and ext must be 1 for all rows.

Value

DataSimObject

Examples

baseline_obj <- create_baseline_object(
  n_trt_int = 100,
  n_ctrl_int = 50,
  n_ctrl_ext = 10,
  covariates = baseline_covariates(
    names = c("age", "score"),
    means_int = c(55, 5),
    means_ext = c(60, 5),
    covariance_int = covariance_matrix(c(5, 1))
  )
)
sim_obj <- create_data_simulation(
  baseline_obj,
  coefficients = c(age = 0.001, score = 1.5),
  event_dist = create_event_dist(dist = "exponential", lambdas = 1 / 36)
)
data_sim_list <- generate(sim_obj, treatment_hr = c(0.5, 1), drift_hr = 0.5)