upper_risk_difference {precisely}

Estimate sample size based on probability that upper limit is below level of concern.

Description

These functions calculate sample size based on probability that upper limit is below level of concern. The idea behind this approach is to use precision to provide support for the absence of effect. These functions calculate sample size where, when the true effect is null, the upper limit of the confidence interval of the estimate of interest has a probability of being at or under a specified level of concern.

Usage

upper_risk_difference(
  upper_limit,
  prob,
  exposed,
  unexposed,
  group_ratio,
  ci = 0.95
)

upper_risk_ratio(upper_limit, prob, exposed, unexposed, group_ratio, ci = 0.95)

upper_rate_difference(
  upper_limit,
  prob,
  exposed,
  unexposed,
  group_ratio,
  ci = 0.95
)

upper_rate_ratio(upper_limit, prob, exposed, unexposed, group_ratio, ci = 0.95)

upper_odds_ratio(
  upper_limit,
  prob,
  exposed_cases,
  exposed_controls,
  group_ratio,
  ci = 0.95
)

Arguments

upper_limit

The upper limit of the confidence interval, a level of concern.

prob

The probability of the estimated upper limit of the confidence interval being at or below the level of concern.

exposed

The risk or rate among the exposed cohort.

unexposed

The risk or rate among the unexposed cohort.

group_ratio

In cohort studies, the ratio of the unexposed to the exposed. In case-control studies, the ratio of the controls to the cases.

ci

The confidence interval as a probability or percent. Default is .95.

exposed_cases

The proportion of exposed cases.

exposed_controls

The proportion of exposed controls.

Value

a tibble with sample size, effect measure, upper limit, and probability

References

Rothman, K.J. and Greenland, S. 2018. Planning Study Size Based on Precision Rather Than Power. 29(5):599-603.

Examples

# From Rothman and Greenland 2018

upper_rate_ratio(
  upper_limit = 2,
  prob = .90,
  exposed = .01,
  unexposed = .01,
  group_ratio = 1
)