plotNsibs {powerpkg} | R Documentation |
plotNsibs: Create power plots for an affected sib pair linkage study
Description
Plots the required sample sizes needed to detect linkage in an affected sib pair linakge study as a function of lambda sib, under the assumption that lambda sib = lambda off.
Usage
plotNsibs(alpha = 0.001, power = 0.85,...)
Arguments
alpha |
the Type 1 error rate (significance level). |
power |
the power to detect linkage. |
... |
additional arguments for plot |
Details
Assumes that lambda sib = lambda off.
Value
Creates a plot, and returns a table of the data that generated the plot. In this table, the first column gives the lambda sib value, while the second column gives the corresponding number of affected sib pairs needed to have the desired power.
Warning
Makes the simplifying assumptions that (1) all families will have exactly two affected sibpairs; and that (2) the identity-by-descent status in the ASPs can be determined unambiguously
Note
These are based on a Mathematica notebook created by Martin Farrall.
Author(s)
Daniel E. Weeks
See Also
Examples
## Plot the required sample sizes in an affected sib pair linkage study as
## a function of lambda sib required to have 85 percent power at an alpha
## level of 0.001, under the assumption that lambda sib = lambda off.
plotNsibs(alpha=0.001,power=0.85)