powerEpiInt.default1 {powerSurvEpi} | R Documentation |
Power Calculation Testing Interaction Effect for Cox Proportional Hazards Regression
Description
Power calculation testing interaction effect for Cox proportional hazards regression with two covariates for Epidemiological Studies. Both covariates should be binary variables. The formula takes into account the correlation between the two covariates.
Usage
powerEpiInt.default1(n,
theta,
psi,
p00,
p01,
p10,
p11,
alpha = 0.05)
Arguments
n |
integer. total number of subjects. |
theta |
numeric. postulated hazard ratio. |
psi |
numeric. proportion of subjects died of the disease of interest. |
p00 |
numeric. proportion of subjects taking values |
p01 |
numeric. proportion of subjects taking values |
p10 |
numeric. proportion of subjects taking values |
p11 |
numeric. proportion of subjects taking values |
alpha |
numeric. type I error rate. |
Details
This is an implementation of the power calculation formula derived by Schmoor et al. (2000) for the following Cox proportional hazards regression in the epidemoilogical studies:
h(t|x_1, x_2)=h_0(t)\exp(\beta_1 x_1+\beta_2 x_2 + \gamma (x_1 x_2)),
where both covariates X_1
and X_2
are binary variables.
Suppose we want to check if
the hazard ratio of the interaction effect X_1 X_2=1
to X_1 X_2=0
is equal to 1
or is equal to \exp(\gamma)=\theta
.
Given the type I error rate \alpha
for a two-sided test, the power
required to detect a hazard ratio as small as \exp(\gamma)=\theta
is:
power=\Phi\left(-z_{1-\alpha/2}+\sqrt{\frac{n}{\delta}[\log(\theta)]^2 \psi}\right),
where z_{a}
is the 100 a
-th percentile of the standard normal distribution,
\delta=\frac{1}{p_{00}}+\frac{1}{p_{01}}+\frac{1}{p_{10}}
+\frac{1}{p_{11}},
\psi
is the proportion of subjects died of
the disease of interest, and
p_{00}=Pr(X_1=0,\mbox{and}, X_2=0)
,
p_{01}=Pr(X_1=0,\mbox{and}, X_2=1)
,
p_{10}=Pr(X_1=1,\mbox{and}, X_2=0)
,
p_{11}=Pr(X_1=1,\mbox{and}, X_2=1)
.
Value
The power of the test.
References
Schmoor C., Sauerbrei W., and Schumacher M. (2000). Sample size considerations for the evaluation of prognostic factors in survival analysis. Statistics in Medicine. 19:441-452.
See Also
powerEpiInt.default0
, powerEpiInt2
Examples
# Example at the end of Section 4 of Schmoor et al. (2000).
# p00, p01, p10, and p11 are calculated based on Table III on page 448
# of Schmoor et al. (2000).
powerEpiInt.default1(n = 184,
theta = 3,
psi = 139 / 184,
p00 = 50 / 184,
p01 = 21 / 184,
p10 = 78 / 184,
p11 = 35 / 184,
alpha = 0.05)