| getwm {pocrm} | R Documentation |
Obtain the working models for use in the partial order continual reassessment method (PO-CRM)
Description
getwm returns a matrix of skeleton values corresponding to the possible orderings of the toxicity probabilities in a Phase I trial of combined drugs for use in the partial order continual reassessment method (PO-CRM).
Usage
getwm(orders, skeleton)
Arguments
orders |
A matrix specifying the possible orderings of the combinations with regards to their toxicity probabilities. |
skeleton |
A vector of values for the initial guesses of toxicity probabilities. The location of these values will be adjusted to correspond to the orderings specified by orders. |
Details
Based on the matrix of possible orderings, the skeleton values are adjusted to correspond to the possible orderings of the toxicity probabilities. See Table 4 of Wages, Conaway and O'Quigley (2011).
Value
alpha |
A matrix of skeleton values corresponding to the possible orderings of the toxicity probabilities specified by orders. |
References
Wages, Conaway and O'Quigley (2011). Dose-finding design for multi-drug combinations. Clinical Trials 8(4): 380-389.
Examples
#All specifications refer to example in Wages, Conaway and O'Quigley (2011).
#Specify the possible orderings from Table 2
orders<-matrix(nrow=8,ncol=8)
orders[1,]<-c(1,2,3,4,5,6,7,8)
orders[2,]<-c(1,3,2,4,5,6,7,8)
orders[3,]<-c(1,2,3,5,4,6,7,8)
orders[4,]<-c(1,2,3,4,5,7,6,8)
orders[5,]<-c(1,3,2,5,4,6,7,8)
orders[6,]<-c(1,3,2,4,5,7,6,8)
orders[7,]<-c(1,2,3,5,4,7,6,8)
orders[8,]<-c(1,3,2,5,4,7,6,8)
#Specify the skeleton values provided in Table 4.
skeleton<-c(0.01,0.03,0.10,0.20,0.33,0.47,0.60,0.70)
getwm(orders,skeleton)