nonmemboxcox {pmxcv}

Box-Cox transform typically used in NONMEM

Description

Parameters are typically treated as lognormally-distributed by NONMEM users. Box-Cox transforms are typically applied to the exponentiated individual ETA parameters; this means the parameter is neither Box-Cox distributed nor lognormally-distributed, but both. To get the "Box-Cox Transform" as it would be relevant for CV% calculation, these properties have to be considered.

Usage

nonmemboxcox(x, lambda, theta = 1, inv = FALSE)

Arguments

x

random vector. Must be positive.

lambda

shape parameter

theta

centrality parameter

inv

inverse transform

Value

Box-Cox transformed or untransformed vector