pk_curve {pmxTools}

Provide concentration-time curves.

Description

Provide concentration-time curves.

Usage

pk_curve(
  t,
  model = "1cmt_oral",
  params = list(ka = 2.77, CL = 2.5, V = 25),
  dose = 600,
  ii = 24,
  addl = 0,
  ss = F
)

Arguments

t

Observation time in h, specified as a vector.

model

The model to use. Must be one of "1cmt_bolus", "1cmt_infusion", "1cmt_oral", "2cmt_bolus", "2cmt_infusion", "2cmt_oral", "3cmt_bolus", "3cmt_infusion", "3cmt_oral". The default is "1cmt_oral".

params

A named list containing parameter values for the selected model type.

dose

Dose amount.

ii

Interdose interval (or tau), in hours (default 24).

addl

Number of additional doses (default 0).

ss

Assume steady state concentration (default FALSE).

Value

A data frame containing times (t) and concentrations (cp).

Author(s)

Justin Wilkins, [e-mail]

Examples

plot(pk_curve(t=seq(0,72,by=0.1), model="3cmt_oral", ii=12, addl=5,
  params=list(CL=2.5, V1=25, V2=2, V3=5, Q2=0.5, Q3=0.25, ka=1)), type="l")