calc_ss_2cmt {pmxTools} | R Documentation |
Calculate C(t) for a 2-compartment linear model at steady-state
Description
Calculate C(t) for a 2-compartment linear model at steady-state
Usage
calc_ss_2cmt(tad, tau, dose, dur = NULL, tinf = NULL, ...)
calc_ss_2cmt_linear_bolus(tad, tau, dose, ...)
calc_ss_2cmt_linear_infusion(tad, tau, dose, tinf, ...)
calc_ss_2cmt_linear_oral_0(tad, tau, dose, dur, ...)
calc_ss_2cmt_linear_oral_1_lag(tad, tau, dose, ...)
calc_ss_2cmt_linear_oral_0_lag(tad, tau, dose, dur, ...)
calc_ss_2cmt_linear_oral_1(tad, tau, dose, ...)
Arguments
tad |
Time after dose (h) |
tau |
Dosing interval (h) |
dose |
Dose |
dur |
Duration of zero-order absorption (h) |
tinf |
Duration of infusion (h) |
... |
Passed to 'calc_derived_2cpt()' |
Value
Concentration of drug at requested time (t
) at steady-state, given provided set of parameters and variables.
Functions
-
calc_ss_2cmt_linear_bolus()
: Calculate C(t) for a 2-compartment linear model with IV bolus dosing at steady-state -
calc_ss_2cmt_linear_infusion()
: Calculate C(t) for a 2-compartment linear model with infusion at steady state -
calc_ss_2cmt_linear_oral_0()
: Calculate C(t) for a 2-compartment linear model at steady-state with zero-order oral dosing -
calc_ss_2cmt_linear_oral_1_lag()
: Calculate C(t) for a 2-compartment linear model at steady-state with first-order oral dosing -
calc_ss_2cmt_linear_oral_0_lag()
: Calculate C(t) for a 2-compartment linear model at steady-state with zero-order oral dosing and a lag time -
calc_ss_2cmt_linear_oral_1()
: Calculate C(t) for a 2-compartment linear model at steady-state with first-order oral dosing
Author(s)
Justin Wilkins, justin.wilkins@occams.com
References
Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.
Examples
Ct <- calc_ss_2cmt_linear_bolus(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
dose = 10, tau=24)
Ct <- calc_ss_2cmt_linear_infusion(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
dose = 10, tinf = 1, tau = 12)
Ct <- calc_ss_2cmt_linear_oral_0(tad = 23, CL = 2.5, V1 = 20, V2 = 30, Q = 0.5,
dose = 1000, dur = 1, tau = 24)
Ct <- calc_ss_2cmt_linear_oral_1_lag(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
dose = 1000, ka = 1, tau=24, tlag=2)
Ct <- calc_ss_2cmt_linear_oral_0_lag(tad = 23, CL = 2.5, V1 = 20, V2 = 30, Q = 0.5,
dose = 1000, dur = 1, tau = 24, tlag=2)
Ct <- calc_ss_2cmt_linear_oral_1(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
dose = 1000, ka = 1, tau=24)