models {pksensi}

Example PK Model for Sensitivity Analysis

Description

The example PK model that were used in sensitivity testing. Three examples are included: Flip-flop pharmacokinetic model, one-compartment toxicokinetic model from httk (Pearce et al. 2017), and acetaminophen pharmacokinetic model (Zurlinden et al. 2016).

Usage

FFPK(params, time, dose = 1)

pbtk1cpt_model()

pbpk_apap_model()

Arguments

params

a numeric vector to define the input parameter value.

time

a numeric vector to define the given time point(s).

dose

a numeric value to define the given dose in flip-flop model.

Functions

• pbtk1cpt_model(): Download pbtk1cpt.model file.

• pbpk_apap_model(): Download pbpk_apap.model file.

References

Pearce, R. G., Setzer, R. W., Strope, C. L., Wambaugh, J. F., & Sipes, N. S. (2017). httk: R package for high-throughput toxicokinetics. Journal of Statistical Software, 79(4), 1-26.

Zurlinden, T. J., & Reisfeld, B. (2016). Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach. European journal of drug metabolism and pharmacokinetics, 41(3), 267-280.

Examples

params <- c(F = 0.9, KA = 1.2, KE = 0.2, V = 1.5)
t <- seq(0, 12, 0.1)
C <-FFPK(params = params, time = t)
plot(t, C, type = "l", xlab = "time", ylab = "concentration")