| APAP {pksensi} | R Documentation |
Pharmacokinetic Dataset of Acetaminophen
Description
The Acetaminophen dataset contains a human experiment of pharmacokinetic data for acetaminophen and it's major metabolites acetaminophen-glucuronide and acetaminophen-sulfate.
Usage
APAP
Format
A data frame containing the following columns:
Wt: averaged weight of the study population (kg).
Dose: given oral dose of acetaminophen administered (mg/kg).
Time: time after drug administration (hr).
APAP: concentration of acetaminophen in the sample (mg/L).
AG: concentration of acetaminophen-glucuronide in the sample (mg/L).
AS: concentration of acetaminophen-sulfate in the sample (mg/L).
Study: sourced reference.
References
Zurlinden, T. J., & Reisfeld, B. (2016). Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach. European journal of drug metabolism and pharmacokinetics, 41(3), 267-280.