pkr-package {pkr} | R Documentation |
Pharmacokinetics in R
Description
It conducts a noncompartmental analysis(NCA) as closely as possible to the most widely used commercial pharmacokinetic analysis software.
Details
The main functions are
NCA to perform NCA for many subjects. IndiNCA to perform NCA for one subject.
Author(s)
Kyun-Seop Bae <k@acr.kr>, Jee Eun Lee <JeeEun.Lee@fda.hhs.gov>
References
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.
Examples
# Theoph and Indometh data: dose in mg, conc in mg/L, time in h
NCA(Theoph, "Subject", "Time", "conc", dose=320, uConc="mg/L")
NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", uConc="mg/L")
iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC
NCA(Theoph, "Subject", "Time", "conc", dose=320, iAUC=iAUC, uConc="mg/L")
NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", iAUC=iAUC, uConc="mg/L")
# writeLines(NCA(Theoph, "Subject", "Time", "conc", dose=320, report="Text", uConc="mg/L"),
# "Theoph_Linear_CoreOutput.txt")
# writeLines(NCA(Theoph, "Subject", "Time", "conc", dose=320, fit="Log", report="Text",
# uConc="mg/L"), "Theoph_Log_CoreOutput.txt")
# writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", report="Text",
# uConc="mg/L"), "Indometh_Bolus_Linear_CoreOutput.txt")
# writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", fit="Log",
# report="Text", uConc="mg/L"), "Indometh_Bolus_Log_CoreOutput.txt")
# writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Infusion", dur=0.25,
# report="Text", uConc="mg/L"), "Indometh_Infusion_Linear_CoreOutput.txt")
# writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Infusion", dur=0.25,
# fit="Log", report="Text", uConc="mg/L"), "Indometh_Infusion_Log_CoreOutput.txt")
sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], dose=320, concUnit="mg/L")
sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25,
adm="Bolus", concUnit="mg/L")
sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25,
adm="Infusion", dur=0.25, concUnit="mg/L")
iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC
sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], dose=320,
iAUC=iAUC, concUnit="mg/L")
sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25,
adm="Bolus", iAUC=iAUC, concUnit="mg/L")
sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25,
adm="Infusion", dur=0.25, iAUC=iAUC, concUnit="mg/L")
[Package pkr version 0.1.3 Index]