PostP {ph2bye} | R Documentation |
The posterior probability criterion function for Phase II single-arm design
Description
Thall and Simon's criterion function for determining the trial decision boundaries based on the posterior probability.
Usage
PostP(x, n, a, b, p0)
Arguments
x |
the number of responses among |
n |
the number of patients treated by the experimental drug. |
a |
the hyperparameter (shape1) of the Beta prior for the experimental drug. |
b |
the hyperparameter (shape2) of the Beta prior for the experimental drug. |
p0 |
the prespecified reseponse rate. |
Value
prob |
the posterior probability: |
References
Berry, S. M., Carlin, B. P., Lee, J. J., & Muller, P. (2010). Bayesian adaptive methods for clinical trials. CRC press.
Thall, P. F., Simon, R. (1994). Practical Bayesian guidelines for phase IIB clinical trials. Biometrics 50: 337-349.
Yin, G. (2013). Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. New York: Wiley.
Examples
PostP(8,15,1,1,0.8)