Pbc3 {pec}

Pbc3 data

Description

PBC3 was a multi-centre randomized clinical trial conducted in six European hospitals. Between 1 Jan. 1983 and 1 Jan. 1987, 349 patients with the liver disease primary biliary cirrhosis (PBC) were randomized to either treatment with Cyclosporin A (CyA, 176 patients) or placebo (173 patients). The purpose of the trial was to study the effect of treatment on the survival time. However, during the course of the trial an increased use of liver transplantation for patients with this disease made the investigators redefine the main response variable to be time to “failure of medical treatment” defined as either death or liver transplantation. Patients were then followed from randomization until treatment failure, drop-out or 1 Jan, 1989; 61 patients died (CyA: 30, placebo: 31), another 29 were transplanted (CyA: 14, placebo: 15) and 4 patients were lost to follow-up before 1 Jan. 1989. At entry a number of clinical, biochemical and histological variables, including serum bilirubin, serum albumin, sex, age were recorded.

Format

A data frame with 349 observations on the following 15 variables.

ptno

patient identification

unit

hospital (1: Hvidovre, 2: London, 3: Copenhagen, 4: Barcelona, 5: Munich, 6: Lyon)

tment

treatment (0: placebo, 1: CyA)

sex

(1: males, 0: females)

age

age in years

stage

histological stage (1, 2, 3, 4)

gibleed

previous gastrointestinal bleeding (1: yes, 0: no)

crea

creatinine (micromoles/L)

alb

albumin (g/L)

bili

bilirubin (micromoles/L)

alkph

alkaline phosphatase (IU/L)

asptr

aspartate transaminase (IU/L)

weight

body weight (kg)

days

observation time (days)

status

status at observation time (0: censored, 1: liver transplantation, 2 : dead)

Source

Andersen and Skovgaard. Regression with linear predictors.

References

Andersen and Skovgaard. Regression with linear predictors. Springer, 2010.

Examples

data(Pbc3)