| lac_operon_net {pastboon} | R Documentation |
The lactose operon Boolean network
Description
The lactose operon (lac operon) Boolean network as proposed by Veliz-Cuba and Stigler.
Usage
data(lac_operon_net)Details
The data consists of an object lac_operon_net of the BooleanNetwork class from the BoolNet package, describing the lac operon gene regulatory network with 10 genes and 3 inputs. The three inputs collectively indicate the concentration of glucose and lactose. Based on the synchronous update scheme, when extracellular glucose is available, the lac operon is OFF (having one steady-state attractor where all genes are OFF). Otherwise, depending on the extracellular lactose concentration, the operon will be OFF, bistable (having two attractors), or ON (all genes are ON).
References
Veliz-Cuba, A., & Stigler, B. (2011). Boolean models can explain bistability in the lac operon. Journal of computational biology, 18(6), 783-794.
Examples
# load the network
data(lac_operon_net)
# the network is stored in a variable called 'lac_operon_net'
print(lac_operon_net)