dominant1 {paramlink2}

Dominant linkage analysis example

Description

A dataset with SNP genotypes for 14 members of a pedigree affected with a dominant disorder.

Usage

dominant1

Format

A list with 3 elements:

• ped: A pedtools::ped object describing a pedigree with 19 individuals, including genotypes for 14 members at 248 markers on Chromosome 1.

• aff: A vector indicating the affected pedigree members.

• map: A data frame with 3 columns (chrom, marker, cm) describing the centiMorgan positions of the markers.

Examples

data(dominant1)
ped = dominant1$ped
aff = dominant1$aff
model = diseaseModel("AD")

# Compute singlepoint LODs
lods = lod(ped, aff = aff, model = model)

# LOD score graph
plot(lods)