hypertension {npordtests}

Hypertension data

Description

This data presented by Dmitrienko et al. (2006) is to examine the effect of different drug doses on diastolic blood pressure.

Usage

data("hypertension")

Format

A data frame with 68 observations on the following 2 variables.

doseLevel

Dose levels: A: Placebo, B: Dose 10 mg/day, C: Dose 20 mg/day, D: Dose 40 mg/day

rdbp

Mean reduction in diastolic blood pressure

Details

Patients with hypertension were randomized into four groups with different dose levels, 0, 10, 20, and 40 mg/day, where the group with 0 mg/day was the placebo group. The number of patients in each group were 17, 17, 18, and 16, respectively. The complete data can be found at the Dmitrienko et al.(2006) or Shan et al. (2014).

Source

Dmitrienko, A., Chuang-Stein, C. and D’Agostino, R. (2006). Pharmaceutical Statistics Using SAS: A Practical Guide (SAS Press). SAS Institute, 1 edition.

References

Shan, G., Young, D. and Kang, L. (2014). A New Powerful Nonparametric Rank Test for Ordered Alternative Problem. PLoS ONE, 9:11, doi:10.1371/journal.pone.0112924.

Examples

data(hypertension)
levels(hypertension$doseLevel) <- c("placebo", "10", "20", "40")
boxplot(rdbp~doseLevel,data=hypertension,xlab="Dose level",ylab="Mean reduction in dbp")