updateOncologyXenograftSimeoni2004 {nlmixr2lib}

Update an oncology xenograft model based on Simeoni 2004

Description

Update an oncology xenograft model based on Simeoni 2004

Usage

updateOncologyXenograftSimeoni2004(
  object,
  ncmt,
  damagedCmtName = "damagedCells",
  drugEffectName = "drugEffectCyclingCells",
  undamagedCmtName = "cyclingCells",
  tumorVolName = "tumorVol",
  transitRateName = "damageTransit"
)

Arguments

object

Fitted object or function specifying the model.

ncmt

The desired number of damaged cell compartments

damagedCmtName, undamagedCmtName, tumorVolName

character string names for the compartments for damaged cells, undamaged cells, and the calculated tumor volume (the sum of undamaged and damaged cells)

drugEffectName, transitRateName

character string names of the drug effect and transit rate (as used in the model block)

Value

An updated model with the new number of compartments

Examples

library(rxode2)
readModelDb("oncology_xenograft_simeoni_2004") %>%
  updateOncologyXenograftSimeoni2004(ncmt = 5)