Quinidine {nlme}

Quinidine Kinetics

Description

The Quinidine data frame has 1471 rows and 14 columns.

Format

This data frame contains the following columns:

Subject

a factor identifying the patient on whom the data were collected.

time

a numeric vector giving the time (hr) at which the drug was administered or the blood sample drawn. This is measured from the time the patient entered the study.

conc

a numeric vector giving the serum quinidine concentration (mg/L).

dose

a numeric vector giving the dose of drug administered (mg). Although there were two different forms of quinidine administered, the doses were adjusted for differences in salt content by conversion to milligrams of quinidine base.

interval

a numeric vector giving the when the drug has been given at regular intervals for a sufficiently long period of time to assume steady state behavior, the interval is recorded.

Age

a numeric vector giving the age of the subject on entry to the study (yr).

Height

a numeric vector giving the height of the subject on entry to the study (in.).

Weight

a numeric vector giving the body weight of the subject (kg).

Race

a factor with levels Caucasian, Latin, and Black identifying the race of the subject.

Smoke

a factor with levels no and yes giving smoking status at the time of the measurement.

Ethanol

a factor with levels none, current, former giving ethanol (alcohol) abuse status at the time of the measurement.

Heart

a factor with levels No/Mild, Moderate, and Severe indicating congestive heart failure for the subject.

Creatinine

an ordered factor with levels < 50 < >= 50 indicating the creatinine clearance (mg/min).

glyco

a numeric vector giving the alpha-1 acid glycoprotein concentration (mg/dL). Often measured at the same time as the quinidine concentration.

Details

Verme et al. (1992) analyze routine clinical data on patients receiving the drug quinidine as a treatment for cardiac arrhythmia (atrial fibrillation or ventricular arrhythmias). All patients were receiving oral quinidine doses. At irregular intervals blood samples were drawn and serum concentrations of quinidine were determined. These data are analyzed in several publications, including Davidian and Giltinan (1995, section 9.3).

Source

Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.25)

Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, Chapman and Hall, London.

Verme, C. N., Ludden, T. M., Clementi, W. A. and Harris, S. C. (1992), Pharmacokinetics of quinidine in male patients: A population analysis, Clinical Pharmacokinetics, 22, 468-480.