modlib_tmdd {mrgsolve}

modlib: Target mediated disposition model

Description

modlib: Target mediated disposition model

Arguments

...

passed to update

Parameters

• KEL: elimination rate constant

• KTP: tissue to plasma rate constant

• KPT: plasma to tissue rate constant

• VC: volume of distribution

• KA1, KA2: absorption rate constants

• KINT: internalization rate constant

• KON: association rate constant

• KOFF: dissociation rate constant

• KSYN: target synthesis rate

• KDEG: target degredation rate constant

Compartments

• CENT: unbound drug in central compartment

• TISS: unbound drug in tissue compartment

• REC: concentration of target

• RC: concentration of drug-target complex

• EV1, EV2: extravascular dosing compartments

Output variables

• CP: unbound drug in the central compartment

• TOTAL: total concentration of target (complexed and uncomplexed)