modTurPoint {modTurPoint}

Modified Turning Point Method for ED50 Estimation

Description

50 percent effective dose (abbreviated as ED50) is one of the most concerns in the field of Anesthesiology. There are many methods to estimate ED50 and its confidence interval. Turning point method is one of them proposed by Choi in 1990 and here is the modified function to realize the ED50 estimation.

Usage

modTurPoint(doseSeries, onlyTurPoint = FALSE, confidence = 0.95)

Arguments

doseSeries

A numeric vector. It can be the whole dose sequence given in a group of experiments in the order. And it can also be the turning point sequence calculated.

onlyTurPoint

A logical value indicating whether the doseSeries is a turning point sequence or not, the defaut is value is FALSE.

confidence

A value ranging from 0 to 1 that represents the confidence level. The default value is 0.95.

Value

A list:

Estimate

The point estimate of ED59 using modified turning point method.

Confidence

Confidence value input.

CI.lower

The lower bound of confidence interval under a certain confidence level.

CI.upper

The upper bound of confidence interval under a certain confidence level.

References

Choi SC Interval estimation of the LD50 based on an up-and-down experiment. Biometrics 1990; 46: 485-92.

Examples

library(modTurPoint)
dose1 <- c(3.1, 3.2, 3.3, 3.2, 3.1, 3.2, 3.3, 3.2, 3.3)
modTurPoint(doseSeries = dose1, confidence = 0.9)
dose2 <- c(3.25, 3.15, 3.25, 3.25)
modTurPoint(doseSeries = dose2, onlyTurPoint = TRUE, confidence = 0.9)