hormesis {mixtox} | R Documentation |
Non-monotonic Concentration-response Data
Description
Two ionic liquids: 1-Octyl-3-methylimidazolium chloride (Omim) and
1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
Two organic solvents: Acetonitrile(ACN) and acetone.
The concentration-response data include the effect of these four compounds
on firefly luciferase.
Those concentration-responses were fitted using non-monotonic models.
Usage
data(hormesis)
Format
A list with non-monotonic concentration-responses of four chemicals and associated fitting information.
OmimCl$x
a numeric vector of concentrations
OmimCl$y
a numeric matrix of responses
OmimCl$name
name of test substance
OmimCl$concNum
the number of concentrations
OmimCl$tierNum
the number of repetitions
OmimCl$type
type of test substance
sgl$model
model used to fit the concentration-response data
sgl$param
fitted coefficients of those curves corresponding to sgl$model
sgl$minx
numeric vector with multiple concentrations that induce maximun stimulation
sgl$miny
the largest stimulation
Details
The non-monotonic concentration-responses need to be scaled into [0, 1] using the following equation:
where is the average of controls for inhibition test or the average
of the maximum effect for the stimulation test and
the average
effect of the
treatment.
Source
Eexperiments were conducted in our lab. Detailed descripttion can be found in references
References
Zhu X-W, et.al. 2013. Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration. Ecotoxicol. Environ. Saf. 89:130-136.
Examples
#example 1
## Retrive the toxicity data of acetonitrile on firefly luciferase.
hormesis$ACN
#example 2
## Retrive the minx of OmimCl, HmimCl, ACN, and Acetone
hormesis$sgl$minx