hormesis {mixtox} | R Documentation |
Non-monotonic Concentration-response Data
Description
Two ionic liquids: 1-Octyl-3-methylimidazolium chloride (Omim) and
1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
Two organic solvents: Acetonitrile(ACN) and acetone.
The concentration-response data include the effect of these four compounds
on firefly luciferase.
Those concentration-responses were fitted using non-monotonic models.
Usage
data(hormesis)
Format
A list with non-monotonic concentration-responses of four chemicals and associated fitting information.
OmimCl$x
a numeric vector of concentrations
OmimCl$y
a numeric matrix of responses
OmimCl$name
name of test substance
OmimCl$concNum
the number of concentrations
OmimCl$tierNum
the number of repetitions
OmimCl$type
type of test substance
sgl$model
model used to fit the concentration-response data
sgl$param
fitted coefficients of those curves corresponding to sgl$model
sgl$minx
numeric vector with multiple concentrations that induce maximun stimulation
sgl$miny
the largest stimulation
Details
The non-monotonic concentration-responses need to be scaled into [0, 1] using the following equation:
E = \frac{{{I_0} - {I_i}}}{{{I_0}}}
where I_0
is the average of controls for inhibition test or the average
of the maximum effect for the stimulation test and I_i
the average
effect of the i^{th}
treatment.
Source
Eexperiments were conducted in our lab. Detailed descripttion can be found in references
References
Zhu X-W, et.al. 2013. Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration. Ecotoxicol. Environ. Saf. 89:130-136.
Examples
#example 1
## Retrive the toxicity data of acetonitrile on firefly luciferase.
hormesis$ACN
#example 2
## Retrive the minx of OmimCl, HmimCl, ACN, and Acetone
hormesis$sgl$minx