cytotox {mixtox} | R Documentation |
Cytotoxicity of Heavy Metal Ions and Ionic Liquids on MCF-7
Description
Chemicals include four heavy metal ions:
{\rm{NiN}}{{\rm{O}}_{\rm{3}}}\cdot 6{{\rm{H}}_{\rm{2}}}{\rm{O}}
(Ni),
{\rm{ZnS}}{{\rm{O}}_{\rm{4}}} \cdot {\rm{7}}{{\rm{H}}_{\rm{2}}}{\rm{O}}
(Zn),
{\rm{CuS}}{{\rm{O}}_{\rm{4}}} \cdot 5{{\rm{H}}_{\rm{2}}}{\rm{O}}
(Cu), and
{\rm{MnC}}{{\rm{l}}_{\rm{2}}} \cdot 4{{\rm{H}}_{\rm{2}}}{\rm{O}}
(Mn);
four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim),
1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate
(Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
The concentration-response data include the cytotoxicity of eight compounds,
two mixtures designed by eecr, and ten mixtures designed by udcr.
The fitting information of eight chemicals and a total of 12 mixtures.
Usage
data(cytotox)
Format
A list with concentration-response data of 8 chemicals, 2 eecr mixtures, 10 udcr mixtures, and associated fitting information.
Ni$x
a numeric vector of test concentrations
Ni$y
a numeric matrix of responses
Ni$name
test substances
Ni$concNum
the number of test concentrations
Ni$tierNum
the number of repetitions
Ni$type
type of test substance: single chemicals or mixtures
sgl$model
models used to fit the concentration-response data of individual chemicals
sgl$param
fitted coefficients of concentration-response curves
udcr.mix$model
models used to fit the concentration-response data of udcr mixtures
udcr.mix$param
fitted coefficients of the concentration-response curves corresponding to udcr.mix$model
$udcr.pct
the proportion of individual chemicals in udcr mixtures
Details
Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones:
E = \frac{{{I_0} - {I_i}}}{{{I_0}}}
where I_0
is the average of controls for inhibition tests or the average
of the maximum effect for stimulation tests and I_i
the average
effect of the i^{th}
treatment.
Source
The cytotoxicity experiments were conducted in our lab
Examples
# example 1
## Retrive the toxicity data of Ni on MCF-7.
cytotox$Ni
# example 2
## Retrive the toxicity information of ten udcr mixtures on MCF-7.
cytotox$udcr.mix