cytotox {mixtox} | R Documentation |
Cytotoxicity of Heavy Metal Ions and Ionic Liquids on MCF-7
Description
Chemicals include four heavy metal ions:
(Ni),
(Zn),
(Cu), and
(Mn);
four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim),
1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate
(Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
The concentration-response data include the cytotoxicity of eight compounds,
two mixtures designed by eecr, and ten mixtures designed by udcr.
The fitting information of eight chemicals and a total of 12 mixtures.
Usage
data(cytotox)
Format
A list with concentration-response data of 8 chemicals, 2 eecr mixtures, 10 udcr mixtures, and associated fitting information.
Ni$x
a numeric vector of test concentrations
Ni$y
a numeric matrix of responses
Ni$name
test substances
Ni$concNum
the number of test concentrations
Ni$tierNum
the number of repetitions
Ni$type
type of test substance: single chemicals or mixtures
sgl$model
models used to fit the concentration-response data of individual chemicals
sgl$param
fitted coefficients of concentration-response curves
udcr.mix$model
models used to fit the concentration-response data of udcr mixtures
udcr.mix$param
fitted coefficients of the concentration-response curves corresponding to udcr.mix$model
$udcr.pct
the proportion of individual chemicals in udcr mixtures
Details
Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones:
where is the average of controls for inhibition tests or the average
of the maximum effect for stimulation tests and
the average
effect of the
treatment.
Source
The cytotoxicity experiments were conducted in our lab
Examples
# example 1
## Retrive the toxicity data of Ni on MCF-7.
cytotox$Ni
# example 2
## Retrive the toxicity information of ten udcr mixtures on MCF-7.
cytotox$udcr.mix