PBCseq {mixAK}

Mayo Clinic Primary Biliary Cholangitis (Cirrhosis), sequential data

Description

This data is a continuation of the PBC data set (pbc), and contains the follow-up laboratory data for each study patient. An analysis based on the data can be found in Murtagh et al. (1994).

The primary PBC data set contains only baseline measurements of the laboratory paramters. This data set contains multiple laboratory results, but only on the 312 randomized patients. Some baseline data values in this file differ from the original PBC file, for instance, the data errors in prothrombin time and age which were discovered after the orignal analysis (see Fleming and Harrington, 1991, figure 4.6.7).

Usage

data(PBCseq)

Format

a data frame with 1 945 rows and the following variables

id

identification number of a patient

sex

0/1 for male and female

fsex

factor of above

drug

0/1 for placebo and D-penicillamine

fdrug

factor of above

age

age at entry in years

fu.days

total number of follow up days

alive

number of days when the patient is known to be alive and without liver transplantation

status

status at endpoint, 0/1/2 for censored, liver transplant, dead

fstatus

factor of above

delta.death

0/1 censoring indicator for event = death (i.e., liver transplantation means censoring)

delta.ltx.death

0/1 censoring indicator for event = death or liver transplantation

day

number of days between enrollment and this visit date (all measurements below refer to this date)

month

number of months between enrollment and this visit date

ascites

0/1 presence of ascites

fascites

factor of above

hepatom

0/1 presence of hepatomegaly or enlarged liver

fhepatom

factor of above

spiders

0/1 presence of blood vessel malformations in the skin

fspiders

factor of above

edema

presence and status of edema, 0 for no edema, 0.5 for untreated or successfully treated edema, 1 for edema despite diuretic therapy

fedema

factor of above

stage

histologic stage of disease (needs biopsy)

fstage

factor of above

bili

serum bilirubin (mg/dl)

lbili

natural logarithm of above

albumin

serum albumin (mg/dl)

lalbumin

natural logarithm of above

alk.phos

alkaline phosphotase (U/liter)

lalk.phos

natural logarithm of above

chol

serum cholesterol (mg/dl)

lchol

natural logarithm of above

sgot

serum glutamic-oxaloacetic transaminase (the enzyme name has subsequently changed to “ALT” in the medical literature) (U/ml)

lsgot

natural logarithm of above

platelet

platelet count

lplatelet

natural logarithm of above

protime

standardised blood clotting time

lprotime

natural logarithm of above

Source

URL: http://lib.stat.cmu.edu/datasets/

References

Dickson, E. R., Grambsch, P. M., Fleming, T. R., Fisher, L. D., and Langworthy, A. (1989). Prognosis in primary biliary-cirrhosis – Model for decision-making. Hepatology, 10, 1–7.

Fleming, T. R. and Harrington, D. P. (1991). Counting Processes and Survival Analysis. New York: John Wiley and Sons.

Markus, B. H., Dickson, E. R., Grambsch, P. M., Fleming, T. R., Mazzaferro, V., Klintmalm, G. B. G., Wiesner, R. H., Vanthiel, D. H., and Starzl, T. E. (1989). Efficacy of liver-transplantation in patients with primary biliary-cirrhosis. New England Journal of Medicine, 320, 1709–1713.

Murtaugh, P. A., Dickson, E. R., Van Dam, G. M., Malinchoc, M., Grambsch, P. M., Langworthy, A. L., and Gips, C. H. (1994). Primary biliary cirrhosis: Prediction of short-term survival based on repeated patient visits. Hepatology, 20, 126-134.

Therneau, T. M. and Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. New York: Springer-Verlag.

See Also

pbc, pbcseq

Examples

data(PBCseq)
summary(PBCseq)