| dat.cannon2006 {metadat} | R Documentation |
Studies on the Effectiveness of Intensive Versus Moderate Statin Therapy for Preventing Coronary Death or Myocardial Infarction
Description
Results from 4 trials examining the effectiveness of intensive (high dose) versus moderate (standard dose) statin therapy for preventing coronary death or myocardial infarction.
Usage
dat.cannon2006
Format
The data frame contains the following columns:
| trial | character | trial name |
| pop | character | study population (post-ACS: post acute coronary syndrome; stable CAD: stable coronary artery disease) |
| nt | numeric | number of patients in the high dose group |
| nc | numeric | number of patients in the standard dose group |
| ep1t | numeric | number of events in the high dose group for end point 1: coronary death or non-fatal myocardial infarction |
| ep1c | numeric | number of events in the standard dose group for end point 1: coronary death or non-fatal myocardial infarction |
| ep2t | numeric | number of events in the high dose group for end point 2: coronary death or any cardiovascular event (MI, stroke, hospitalization for unstable angina, or revascularization) |
| ep2c | numeric | number of events in the standard dose group for end point 2: coronary death or any cardiovascular event (MI, stroke, hospitalization for unstable angina, or revascularization) |
| ep3t | numeric | number of events in the high dose group for end point 3: cardiovascular death |
| ep3c | numeric | number of events in the standard dose group for end point 3: cardiovascular death |
| ep4t | numeric | number of events in the high dose group for end point 4: non-cardiovascular death |
| ep4c | numeric | number of events in the standard dose group for end point 4: non-cardiovascular death |
| ep5t | numeric | number of events in the high dose group for end point 5: deaths (all-cause mortality) |
| ep5c | numeric | number of events in the standard dose group for end point 5: deaths (all-cause mortality) |
| ep6t | numeric | number of events in the high dose group for end point 6: stroke |
| ep6c | numeric | number of events in the standard dose group for end point 6: stroke |
Details
The data were obtained from Figures 2, 3, 4, and 5 in Cannon et al. (2006). The authors used the Mantel-Haenszel method for combining the results from the 4 trials. This approach is implemented in the rma.mh function.
Concepts
medicine, cardiology, odds ratios, Mantel-Haenszel method
Author(s)
Wolfgang Viechtbauer, wvb@metafor-project.org, https://www.metafor-project.org
Source
Cannon, C. P., Steinberg, B. A., Murphy, S. A., Mega, J. L., & Braunwald, E. (2006). Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. Journal of the American College of Cardiology, 48(3), 438–445. https://doi.org/10.1016/j.jacc.2006.04.070
Examples
### copy data into 'dat' and examine data
dat <- dat.cannon2006
dat
## Not run:
### load metafor package
library(metafor)
### meta-analysis of log odds ratios using the MH method for endpoint 1
res <- rma.mh(measure="OR", ai=ep1t, n1i=nt, ci=ep1c, n2i=nc, data=dat, slab=trial)
print(res, digits=2)
### forest plot
forest(res, xlim=c(-.8,.8), atransf=exp, at=log(c(2/3, 1, 3/2)),
header=TRUE, top=2, cex=1.2, xlab="Odds Ratio")
mtext("(high dose better)", side=1, line=par("mgp")[1]-0.5, at=log(2/3), cex=1.2, font=3)
mtext("(standard dose better)", side=1, line=par("mgp")[1]-0.5, at=log(3/2), cex=1.2, font=3)
## End(Not run)