directpvalcombi {metaMA}

Direct p-value combination

Description

Combines one sided p-values with the inverse normal method.

Usage

directpvalcombi(pvalonesided, nrep, BHth = 0.05)

Arguments

pvalonesided

List of vectors of one sided p-values to be combined.

nrep

Vector of numbers of replicates used in each study to calculate the previous one-sided p-values.

BHth

Benjamini Hochberg threshold. By default, the False Discovery Rate is controlled at 5%.

Value

List

DEindices

Indices of differentially expressed genes at the chosen Benjamini Hochberg threshold.

TestStatistic

Vector with test statistics for differential expression in the meta-analysis.

Note

One-sided p-values are required to avoid directional conflicts. Then a two-sided test is performed to find differentially expressed genes.

Author(s)

Guillemette Marot

References

Hedges, L. and Olkin, I. (1985). Statistical Methods for Meta-Analysis. Academic Press.