scr {mdhglm}

Serum Creatinine data

Description

In clinical trials, various response variables of interest are measured repeatedly over time on the same subject, which can be analysed by using the mdhglm package. At the same time, an event time representing recurrent or terminating time is also obtained. For example, consider a clinical study to investigate the chronic renal allograft dysfunction in renal transplants (Sung et al., 1998). The renal function was evaluated from the serum creatinine (sCr) values. Since the time interval between the consecutive measurements differs from patient to patient, we focus on the mean creatinine levels over six months. In addition, a single terminating survival time (graft-loss time), measured by month, is observed from each patient. During the study period, there were 13 graft losses due to the kidney dysfunction. For other remaining patients, we assumed that the censoring occurred at the last follow-up time. Thus, the censoring rate is about 88 percent.

Usage

data("scr")

Format

A data frame with 1395 observations on the following 9 variables.

id

subjects identifier

month

visiting time in months

cr

serum creatinine value

sex

gender (1=male, 0=female)

age

age in years

icr

1/cr

sur_time

graft loss time

status

=1 for occurrence of event, 0=censoring

first

indicator first visit or not (1=first visit, 0=oterwise)

References

Sung, K.H., Kang, K.W., Kang, C.M., Kwak, J.Y., Park, T.S. and Lee, S.Y. (1998). Study on the factors affecting the chronic renal allograft dysfunction. The Korean Journal of Nephrology, 17, 483–493.