cgd {mdhglm}

CGD Infection Data

Description

The CGD data set presented by Fleming and Harrington (1991) and Therneau and Lumley (2015) consists of a placebo-controlled randomized trial of gamma interferon (rIFN-g) in the treatment of chronic granulomatous disease (CGD). 128 patients from 13 centers were tracked for around 1 year. The number (i.e., cluster size) of patients per center ranged from 4 to 26. The survival times are the recurrent infection times of each patient from the different centers. Censoring occurred at the last observation for all patients, except one, who experienced a serious infection on the data he left the study; in the CGD study about 63 per cent of the data were censored. The recurrent infection times for a given patient are likely to be correlated. However, each patient belongs to one of the 13 centers; hence, the correlation may also be attributed to a center effect.

Usage

data("cgd")

Format

A data frame with 203 observations on the following 16 variables.

id

subjects identifier for 128 patients

center

enrolling center for 13 centers

random

date of randomization

treat

a factor with levels placebo and rIFN-g (gamma interferon)

sex

a factor with levels male and female

age

age in years at study entry

height

height in cm at study entry

weight

weight in kg at study entry

inherit

a factor for pattern of inheritance with levels X-linked and autosomal

steroids

use of steroids at study entry with 1 (=yes) and 0(=no)

propylac

use of prophylactic antibiotics at study entry

hos.cat

a factor for centers into 4 goups with levels US:NIH, US:other, Europe:Amsterdam and Europe:other

tstart

start of each time interval

enum

observation number within subject

tstop

end of each time interval

status

status with 1 for infection and 0 for censoring

References

Fleming, T.R. and Harrington, D.P. (1991). Counting Processes and Survival Analysis. John Wiley and Sons, New York.

Therneau, T. and Lumley, T. (2015). survival: Survival Analysis. R package version 2.38-3.