R: Renal transplantation data

renal {joineRML}

R Documentation

Renal transplantation data

Description

This is a dataset on 407 patients suffering from chronic kidney disease who underwent a primary renal transplantation with a graft from a deceased or living donor in the University Hospital of the Catholic University of Leuven (Belgium) between 21 January 1983 and 16 August 2000. Chronic kidney (renal) disease is a progressive loss of renal function over a period of months or years through five stages. Each stage is a progression through an abnormally low and progressively worse glomerular filtration rate (GFR). The dataset records 3 repeated measures (2 continuous and 1 binary), and an event time.

Usage

data(renal)

Format

This is a list with 4 data frames:

prot: repeated measurement data for proteinuria (binary) that measures whether the kidneys succeed in sustaining the proteins in the blood and not discard them in the urine.
haem: repeated measurement data for blood haematocrit level (continuous) that measures whether the kidneys produce adequate amounts of the hormone erythropoietin that regulates the red blood cell production.
gfr: repeated measurement data for GFR (continuous) that measures the filtration rate of the kidneys.
surv: time-to-event data for renal graft failure.

All datasets have the common data columns, which are in long format for the 3 longitudinal data data frames, and 1-per-subject for the time-to-event data frame:

id: number for patient identification.
age: age of patient at day of surgery (years).
weight: preoperative weight of patient (kg).
sex: gender of patient.
fuyears: maximum follow up time, with transplant date as the time origin (years).
failure: censoring indicator (1=graft failure and 0=censored).

The longitudinal datasets only contain 2 further columns:

time

observed time point, with surgery date as the time origin (years).

biomarker value

a recorded measurement of the biomarker taken at time time. The 3 biomarkers (one per data frame) are:

proteinuria: recorded as binary indicator: present or not-present. Present in the prot data.
haematocrit: recorded as percentage (%) of the ratio of the volume of red blood cells to the total volume of blood. Present in the haem data.
gfr: measured as ml/min/1.73m^2. Present in the gfr data.

Source

Dr Dimitris Rizopoulos (d.rizopoulos@erasmusmc.nl).

References