associations {ieugwasr}

Query specific variants from specific GWAS

Description

Every rsid is searched for against each requested GWAS id. To get a list of available GWAS ids, or to find their meta data, use gwasinfo. Can request LD proxies for instances when the requested rsid is not present in a particular GWAS dataset. This currently only uses an LD reference panel composed of Europeans in 1000 genomes version 3. It is also restricted to biallelic single nucleotide polymorphisms (no indels), with European MAF > 0.01.

Usage

associations(
  variants,
  id,
  proxies = 1,
  r2 = 0.8,
  align_alleles = 1,
  palindromes = 1,
  maf_threshold = 0.3,
  opengwas_jwt = get_opengwas_jwt()
)

Arguments

variants

Array of variants e.g. c("rs234", "7:105561135-105563135")

id

Array of GWAS studies to query. See gwasinfo for available studies

proxies

0 or (default) 1 - indicating whether to look for proxies

r2

Minimum proxy LD rsq value. Default=0.8

align_alleles

Try to align tag alleles to target alleles (if proxies = 1). 1 = yes (default), 0 = no

palindromes

Allow palindromic SNPs (if proxies = 1). 1 = yes (default), 0 = no

maf_threshold

MAF threshold to try to infer palindromic SNPs. Default = 0.3.

opengwas_jwt

Used to authenticate protected endpoints. Login to https://api.opengwas.io to obtain a jwt. Provide the jwt string here, or store in .Renviron under the keyname OPENGWAS_JWT.

Value

Dataframe