hiv {icensBKL}

HIV Data on Hemophilia Patients

Description

The data arises from a 16-center prospective study in the 1980s on people with hemophilia for the purpose of investigating the risk of HIV-1 infection on these people. The event of interest is the HIV-1 infection. Patients received either no or low-dose factor VIII concentrate. Times are recorded in quarters and 0 represents January 1, 1978, the start of the epidemic and the time at which all patients are considered to be negative.

Usage

data(hiv)

Format

a data frame with 368 rows and the following variables

id

patient identification number

low

lower limit of interval (lower,upper] that contains the event of interest (quarters).

upp

upper limit of interval (lower,upper] that contains the event of interest (quarters). It is NA for right-censored observations.

treat

treatment regimen

0 = no =

no factor VIII concentrate

1 = low dose =

low-dose factor VIII concentrate

Source

Sun, J. (2006). The Statistical Analysis of Interval-censored Failure Time Data. New York: Springer. ISBN 978-0387-32905-5. Table A.2.

References

Goedert, J. J., Kessler, C. M., Aledort, L. M., Biggar, R. J., Andes, W. A., White, G. C., Drummond, J. E., Vaidya, K., Mann, D. L., Eyster, M. E. and et al. (1989). A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. The New England Journal of Medicine, 321, 1141-1148.

Kroner, B. L., Rosenberg, P. S., Aledort, L. M., Alvord, W. G., and Goedert, J. J. (1994) HIV-1 infection incidence among persons with hemophilia in the United States and western Europe, 1978-1990. Multicenter Hemophilia Cohort Study. Journal of Acquired Immune Deficiency Syndromes, 7, 279-286.

Sun, J. (2006). The Statistical Analysis of Interval-censored Failure Time Data. New York: Springer. ISBN 978-0387-32905-5. Section 3.4.

Examples

data("hiv", package="icensBKL")
summary(hiv)