hiscr {hidradenitis}

Calculates HiSCR scores given a percentage parameter.

Description

Calculates HiSCR scores given a percentage parameter.

Usage

hiscr(
  baseline_abscess,
  baseline_nodule,
  baseline_fistula,
  timepoint_abscess,
  timepoint_nodule,
  timepoint_fistula,
  percentage
)

Arguments

baseline_abscess

Integer vector representing the abscess count at baseline.

baseline_nodule

Integer vector representing the inflammatory nodule count at baseline.

baseline_fistula

Integer vector representing the draining fistula count at baseline.

timepoint_abscess

Integer vector representing the abscess count at the time point of interest.

timepoint_nodule

Integer vector representing the inflammatory nodule count at the time point of interest.

timepoint_fistula

Integer vector representing the draining fistula count at the time point of interest.

percentage

Numeric value specifying the percentage required for HiSCR (e.g., 50 for HiSCR50, 75 for HiSCR75, etc.).

Value

A logical vector indicating whether the HiSCR response is achieved for each set of input parameters.

References

Kimball, A B et al. “HiSCR (Hidradenitis Suppurativa Clinical Response): a novel clinical endpoint to evaluate therapeutic outcomes in patients with hidradenitis suppurativa from the placebo-controlled portion of a phase 2 adalimumab study.” Journal of the European Academy of Dermatology and Venereology : JEADV vol. 30,6 (2016): 989-94. doi:10.1111/jdv.13216

Examples

hiscr(
  baseline_abscess = c(3, 2, 4),
  baseline_nodule = c(5, 4, 6),
  baseline_fistula = c(2, 1, 3),
  timepoint_abscess = c(1, 1, 2),
  timepoint_nodule = c(2, 3, 2),
  timepoint_fistula = c(2, 1, 3),
  percentage = 50
)