IBCSG_curr {hdbayes}

International Breast Cancer Study Group (IBCSG) Trial VI Data

Description

A data set from the IBCSG Trial VI investigating both the duration of adjuvant chemotherapy (3 versus 6 initial cycles of oral cyclophosphamide, methotrexate, and fluorouracil (CMF)) and the reintroduction of single courses of delayed chemotherapy in node-positive premenopausal breast cancer patients. The study results were described by IBCSG (1996) doi:10.1200/JCO.1996.14.6.1885 and Hürny et al. (1992) doi:10.1016/0959-8049(92)90399-m. This data set only includes patients above the age of 40 (i.e., age \geq 40) and treats the measurements of patients' physical well-being on month 18 as the outcome. The IBCSG_hist data set includes patients from the same study but with age < 40. We can use the IBCSG_hist data as the historical data and the IBCSG_curr data as the current data.

Usage

IBCSG_curr

Format

A data frame with 488 rows and 8 variables:

phys18

outcome variable, integer scores between 0 and 100 measuring the patients' physical well-being on month 18, with a higher score indicating a better physical well-being

phys1

physical well-being scores assessed at the start of the study

n_init_cycles

number of initial cycles of CMF, equal to 3 or 6

reintroduction

indicator of reintroduction of chemotherapy, 0 = no reintroduction, 1 = having reintroduction

age

patient age in years

country

country, ANZ = New Zealand/Australia, CH = Switzerland, SWED = Sweden

nodegp

indicator of number of positive nodes being greater than or equal to 4, 0 = less than 4, 1 = 4+

ER

estrogen receptor (ER) status indicator, 0 = negative, 1 = positive

References

International Breast Cancer Study Group. (1996). Duration and reintroduction of adjuvant chemotherapy for node-positive premenopausal breast cancer patients. Journal of Clinical Oncology, 14(6), 1885–1894.

Hürny, C., Bernhard, J., Gelber, R. D., Coates, A., Castiglione, M., Isley, M., Dreher, D., Peterson, H., Goldhirsch, A., and Senn, H.-J. (1992). Quality of life measures for patients receiving adjuvant therapy for breast cancer: An international trial. European Journal of Cancer, 28(1), 118–124.

Chi, Y.-Y. and Ibrahim, J. G. (2005). Joint models for multivariate longitudinal and Multivariate Survival Data. Biometrics, 62(2), 432–445.